Tonofilament differentiation in human epidermis, isolation. Hair and nail structure and function alfredo rossi, phd, luca barbieri, md, giuseppe pistola, md, paola bonaccorsi, md, and stefano calvieri, phd department of dermatology and plastic surgery policlinico umberto i univ. Make ppt and pptx slideshows easy to view by converting them to pdf. Metastatic sarcomatoid squamous cell carcinoma of the. Assessment of the possible functional significance of these changes requires their correlation with defined stages of. Each half desmosome is anchored to its cell web by 10nm intermediate filaments, the tonofilaments. Sarcomatoid squamous cell carcinoma is a rare and aggressive form of cervical cancer. Epidermal tonofilaments are intermediate filaments with an unusually complex polypeptide chain composition which undergoes profound changes during differentiation. Ultrastructural study an overview sciencedirect topics. Mesothelioma of the tunica vaginalis with berep4 and leum1. We would like to show you a description here but the site wont allow us. Wps pdf tools the best free online pdf converter to. The epidermaldermal junction connecting repositories.
The salivary glands, oral mucosa and jaws constitute a group of lesions which are heterogeneous in nature and are odontogenic, salivary or metastatic in origin. Pdf converter is a online webbased document to pdf converter software. Electron microscopy has advanced now to illustrate the tonofilaments more clearly. Immunofluorescent staining of keratin fibers in cultured. Ppt to pdf convert powerpoint to pdf online for free. Immunofluorescent staining of keratin fibers in cultured cells. Under print quality paper pdf, set the desired quality to an option of your choice. Normal human keratinization processes as demonstrated by. Intermediate filaments show a more complex architecture. A neonate with epidermolysis bullosa herpetiformis ebi. Insert pdf file content into a powerpoint presentation.
When the conversion is done, your ppt, pptx, and pdf files will be automatically deleted. The tonofilaments arrow in one of the cells show early retraction and clumping. The integumentary system pptpowerpoint presentation. You can also use it to create pdf from types of files like word doc, excel xls, powerpoint ppt. Instantly convert text documents, presentations, spreadsheets and images to pdf format with this free online pdf converter. Keratinization or eornifieation was defined by rothman 1 as the transformation of living epithelial cells into horny material, while fleseh 2 has recently described it as a consolidation of fibrous keratin precursors. Enamel is the hardest calcified matrix of the body. At em level, consists of an apical tight junction that is called the zonula occludens. Select the target conversion format, then upload up to 20 documents of supported input formats. In the powerpoint preferences dialog box, click general. The moist lining of the oral cavity that is in continuation with the exterior surface of skin on one end and oesophagus on the other end is. Immunohistochemical and ultrastructural characterization. A cell from the malpighian layer of a case of hailey and haileys disease.
Myoepithelial cells in pathology pubmed central pmc. Convert and create pdf from various types of files like word doc, excel xls, powerpoint ppt. An attachment plaque on the cytoplasmic side anchors tonofilaments which are intermediate filaments. Larger clear cells main secretory cells small darker cells resembling mucussecreting cells, borders all apical surfaces myoepithelial cells spindle shaped masses of myofilaments broader base than lumen broader lumen supports gland and propels sweat to the surface paspositive. Myoepithelial cells are stellateshaped and also known as basket cells. This dual supply allows the ligament to survive following removal of the root apex during certain endodontic procedures. Every cell consists of a cell body from which four to eight processes branch out and embrace the secretory unit. The dermal papillae are nipplelike extensions of the dermis into the epidermis note. Unfortunately, inserting pdf content is not possible when editing a presentation in powerpoint for the web. The protein filaggrin is believed to have an important role in holding them together as tonofibrils. The membranes of adjacent cells do not fuse but are held apart by the. The integumentary system the integumentary system integument is skin skin and its appendages make up the integumentary system a fatty layer hypodermis lies deep to it two distinct regions epidermis dermis functions of skin protection cushions and insulates and is waterproof protects from chemicals, heat, cold, bacteria screens uv synthesizes vitamin d with uv regulates body heat prevents. Top 4 historical models of plasma membrane cell biology.
To the best of our knowledge, this is the first reported case of a paratesticular mesothelioma with coexpression of both berep4 and leum1 despite a reported specificity for adenocarcinoma of 95% and 97%, respectively5 and with abundant psammoma bodies. Crocidolite is a much more potent carcinogen than chrysotile serpentine form. As in desmosomes,hemidesmosomes interact with tonofilament intermediatefilaments. Antibody prepared against a group of keratins purified from human stratum corneum was used to identify cells containing keratins by immunofluorescence. We report a case of metastatic sarcomatoid squamous cell carcinoma sscc of cervix that presented with an anterior chest wall mass. Myoepithelial cells have been described in the salivary glands, lacrimal glands, mammary glands, prostate gland and.
The integumentary system ppt powerpoint presentation, medical notes edurev notes for is made by best teachers who have written some of the best books of. Electron dense substance,and tonofilaments are only found on one side. Tonofilaments are keratin intermediate filaments that makes up tonofibrils in the. Tonofibrils are cytoplasmic protein structures in epithelial tissues that converge at desmosomes. Lss the skin alexandra burkesmith introduction to the skin. Wps pdf tools is one best free online pdf converter for you to easily convert pdf to word, spreadsheet, presentation or image files. Pdf immunocytochemical, electron, and immunoelectronmicroscopical studies have revealed that. A 43yearold hispanic female presented with a twomonth history of a central chest wall mass. Iiiii i ii ii ii immunohistochemical and ultrastructural characterization of tonofilament and hemidesmosome abnormalities in a case of epidermolysis bullosa herpetiformis dowlingmeara seth g. Example binding points of epithelial cells to basal lamina. Electron microscopic findings include lipidlike vacuoles in the corneocytes and granulocytes reduction in tonofilaments. Many experimental studies have shown that microfilaments play an active role in the dilatation and contraction of bile canaliculi.
Convert jpg to pdf free online jpg to pdf converter. To compensate for this inherent limitation, enamel has acquired a complex structural organization and a high degree of mineralization rendered possible by the almost total absence of. The tonofilaments become denser in the spinous layer than the basal cell layer. Manual of histological techniques and their diagnostic application. Scribd is the worlds largest social reading and publishing site. To keep a pdf file as a support document for your presentation insert the entire pdf into the presentation as an object that you can open and view during your presentation. Molecular characterization of clear cell lesions of head. They correspond to the epithelial cell tonofilaments of the old nomenclature. Follow these instructions to set the print quality of the pdf. Electron micrographs show that desmosomes consist of two dense attachment plaques fused with the inner leaflet of the cell membrane of adjacent cells, so that each cell contributes one half of the desmosome figs. This cell shows more complete loss of desmosomes than the cells in figure 4. Convert jpg to pdf online with foxits industryleading jpg to pdf converter. If so, share your ppt presentation slides online with. This protein is known to interact with intermediate filaments.
In sectioned tissue and in culture, keratinocytes of skin and other stratified squamous epitheliawhether human, rabbit or mousestained strongly, indicating homologous amino acid sequences in the keratins of these species. There is prominent clumping of tonofilaments in the cytoplasm of basal keratinocytes, which provides an explanation for the bright eosinophilic cytoplasm and the comparatively small amount of shrinkage that these cells undergo during cell death. The finding of epithelial elements, mature desmosomes, and tonofilaments in the original neoplasm secured the diagnosis of spindlecell squamous carcinoma. Ultrastructural studies have confirmed that lymphocytes attach to basal keratinocytes, resulting in their death by apoptosis. Simple columnar epithelium simple columnar epithelium striated border microvilli arrows goblet cells that secrete mucus are stained light blue the basement membrane. In epithelial cells, tonofilaments loop through desmosomes. Sebaceous and sweat glands authorstream presentation. The following points highlight the top four historical models of plasma membrane.
This group of tumours is termed as clear cell tumours. Save powerpoint presentations as pdf files office support. Genodermatoses and acquired syndromes, part i is the property of its rightful owner. Recent studies have proved that epidermal keratinocytes secrete various cytokines. Tonofilament definition of tonofilament by medical. The cells at this level differ from those in the stratum germinativum, in that the tonofilaments. No file size restrictions, no ad watermarks just a free online tool for creating pdfs from your ppt slides. Download your new pdf and save it to your computer.
243 30 728 733 1609 954 53 213 333 1284 1440 800 888 1238 1079 1588 633 902 1464 492 488 569 1425 430 703 552 853 305 1351 588 961 367 533 635 851 61 72 974